Journal article

Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies

Anna Gonzalez-Neira, Juan Manuel Rosa-Rosa, Ana Osorio, Emilio Gonzalez, Melissa Southey, Olga Sinilnikova, Henry Lynch, Rogier A Oldenburg, Christi J van Asperen, Nicoline Hoogerbrugge, Guillermo Pita, Peter Devilee, David Goldgar, Javier Benitez

BMC GENOMICS | BMC | Published : 2007


BACKGROUND: The recent development of new high-throughput technologies for SNP genotyping has opened the possibility of taking a genome-wide linkage approach to the search for new candidate genes involved in heredity diseases. The two major breast cancer susceptibility genes BRCA1 and BRCA2 are involved in 30% of hereditary breast cancer cases, but the discovery of additional breast cancer predisposition genes for the non-BRCA1/2 breast cancer families has so far been unsuccessful. RESULTS: In order to evaluate the power improvement provided by using SNP markers in a real situation, we have performed a whole genome screen of 19 non-BRCA1/2 breast cancer families using 4720 genomewide SNPs wi..

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University of Melbourne Researchers