Journal article

Antiepileptic drug exposure and major congenital malformations: The role of pregnancy registries

Torbjorn Tomson, Dina Battino, Jacqueline French, Cynthia Harden, Lewis Holmes, Jim Morrow, Elisabeth Robert-Gnansia, Angela Scheuerle, Frank Vajda, Katarina Wide, Jacki Gordon

EPILEPSY & BEHAVIOR | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2007

Abstract

The use of antiepileptic drugs (AEDs) in pregnancy is associated with an increased risk of fetal malformations. Although it is known that AEDs may differ with respect to the type of malformations they can induce, earlier studies have generally lacked the power to demonstrate differences between AEDs in their overall teratogenic potential. Furthermore, there is an urgent need to assess the clinical teratogenic potential of the newer-generation AEDs. Epilepsy and pregnancy registries have been established to provide such information, which is essential for the rational management of women with epilepsy with childbearing potential. The registries also provide opportunities for additional studie..

View full abstract