Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing aqueous outflow

Abstract

PURPOSE: To determine whether there is an association between dietary omega-3 (omega-3) fatty acid intake, age, and intraocular pressure (IOP) caused by altered aqueous outflow. METHODS: Sprague-Dawley rats were fed either omega-3-sufficient (omega-3(+)) or omega-3-deficient (omega-3(-)) diets from conception. The diets had 7% lipid content. The omega-3(+) diet contained safflower, flaxseed, and tuna oils (5.5:1.0:0.5), and the omega-3(-) diet contained safflower oil only. Intraocular pressure was measured at 5 to 40 weeks of age under light anesthesia (omega-3(+), n = 39; omega-3(-), n = 48). Aqueous outflow was determined at 45 weeks in a subgroup of animals (omega-3(+), n = 15; omega-3(-)..