Journal article

L-arginine supplementation in peripheral arterial disease - No benefit and possible harm

Andrew M Wilson, Randall Harada, Nandini Nair, Naras Balasubramanian, John P Cooke

CIRCULATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2007

Abstract

BACKGROUND: L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. L-arginine supplementation improves vascular reactivity and functional capacity in peripheral arterial disease (PAD) in small, short-term studies. We aimed to determine the effects of long-term administration of L-arginine on vascular reactivity and functional capacity in patients with PAD. METHODS AND RESULTS: The Nitric Oxide in Peripheral Arterial Insufficiency (NO-PAIN) study was a randomized clinical trial of oral L-arginine (3 g/d) versus placebo for 6 months in 133 subjects with intermittent claudication due to PAD in a single-center setting. The primary end point was the change at ..

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