Journal article

Selective genotyping reveals association between the epithelial sodium channel gamma-subunit and systolic blood pressure

Cara J Busst, Katrina J Scurrah, Justine A Ellis, Stephen B Harrap

HYPERTENSION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2007

Abstract

Systolic blood pressure is determined in large part by genes. Six independent studies have reported evidence of linkage between systolic pressure and chromosome 16p12 that incorporates SCNN1G, the gene encoding the gamma-subunit of the epithelial sodium channel. We undertook the first comprehensive association analysis of SCNN1G and systolic pressure. To achieve genetic contrast, we sampled unrelated subjects within the upper (mean: 166 mm Hg; n=96) and lower (mean: 98 mm Hg; n=94) 10% of the systolic pressure distribution of 2911 subjects from the Victorian Family Heart Study. We examined genotypes and haplotypes related to 26 single nucleotide polymorphisms across SCNN1G and its promoter. ..

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