Journal article

Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression

Olivier WV Van den Brink, Lea M Durham Delbridge, Thierry Pedrazzini, Franklin L Rosenfeldt, Salvatore Pepe

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | SAGE PUBLICATIONS LTD | Published : 2007

Abstract

INTRODUCTION: The endogenous opioid system has been reported to interact with both the cardiac sympathetic and renin-angiotensin systems in exerting a local regulatory action on the heart. The goal of this investigation was to examine how cardiac levels of enkephalin production are altered in the development of normotensive primary hypertrophy due to elevated intra-cardiac angiotensin II (Ang II) production. METHODS: Atrial and ventricular methionine-enkephalin (ME) levels were measured by quantitative radioimmunoassay in 14 and 28-week-old male transgenic mice (TG1306/1R) and control mice. The TG1306/1R exhibit cardiac specific Ang II overexpression and cardiac hypertrophy, but not hyperten..

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