Journal article

Reduction in hepatitis C-related liver disease associated with GB virus C in human immunodeficiency virus coinfection

Mark D Berzsenyi, D Scott Bowden, Heath A Kelly, Kerrie M Watson, Anne M Mijch, Rachel A Hammond, Suzanne M Crowe, Stuart K Roberts

GASTROENTEROLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2007

Abstract

BACKGROUND & AIMS: It has been reported that GB virus C infection (GBV-C) leads to improved morbidity and mortality in patients with human immunodeficiency virus (HIV) infection. However, GBV-C has no effect on the course of liver disease in hepatitis C virus (HCV) monoinfection. The aim of the study was to determine the influence of GBV-C infection on liver disease in patients with HCV/HIV coinfection. METHODS: Data on 158 HCV/HIV patients were collected from January 1996 to October 2005. Two plasma specimens, collected at least 18 months apart, were tested for GBV-C RNA by reverse transcription-polymerase chain reaction with primers to the NS5B gene and confirmed using E2 gene primers and ..

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