Journal article

Continuous-infusion penicillin home-based therapy for serious infections due to penicillin-susceptible pathogens

Aaron L Walton, Benjamin P Howden, Lindsay M Grayson, Tony M Korman

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | ELSEVIER SCIENCE BV | Published : 2007

Abstract

To evaluate the feasibility of continuous-infusion (CI) penicillin in the treatment of serious bacterial infections, consecutive adult patients with deep-seated infections due to penicillin-susceptible pathogens were treated with CI aqueous penicillin G in a home-based programme, and their treatment outcomes were reviewed. Thirty-one patients with microbiologically proven infections completed the planned course of treatment. Twenty of 31 (65%) were followed for at least 2 months thereafter, and all remained free of relapse. One patient had fever attributable to penicillin hypersensitivity, two patients developed catheter-site infections and one patient developed catheter-related bacteraemia...

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