Journal article

Characterization of the expression and activation of the epidermal growth factor receptor in squamous cell carcinoma of the skin

GB Fogarty, NM Conus, J Chu, G McArthur

BRITISH JOURNAL OF DERMATOLOGY | BLACKWELL PUBLISHING | Published : 2007

Abstract

BACKGROUND: Locally advanced skin cancers including squamous cell carcinoma (SCC) of the skin are increasing in incidence. Patients are often elderly with significant comorbidities and therapy can be difficult. New targeted therapies, such as treatment directed at the epidermal growth factor receptor (EGFR), may be effective and less toxic in these patients. However, before designing appropriate clinical trials it is necessary to characterize the expression and activation of targets such as the EGFR to evaluate the rationale of using EGFR inhibitors (EGFRIs) in the treatment of this type of cancer. OBJECTIVES: To characterize the expression and activation by phosphorylation of EGFR in SCC of..

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University of Melbourne Researchers