Journal article

Metabolic and functional profiling of the normal rat retina

Daniel Sun, Algis J Vingrys, Michael Kalloniatis

JOURNAL OF COMPARATIVE NEUROLOGY | WILEY | Published : 2007

Abstract

We established a metabolic and functional profile map of the normal rat retina, given the premise that: 1) amino acid neurochemistry reflects metabolic integrity and cellular identity, and 2) the permeation of a cation channel probe, agmatine (1-amino-4-guanidobutane, AGB), reflects cation channel functionality. The purpose was to provide a unique method of simultaneously assessing the metabolic and functional characteristics of the normal retina, upon which a comparison can be made to disease models. Quantitative pattern recognition analysis of overlapping amino acid and AGB expression profiles was used to provide a statistically robust classification of all neural elements according to the..

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