Journal article

Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar typhimurium

Jason D Price, Kim R Simpfendorfer, Radhakrishnam R Mantena, James Holden, William R Heath, Nico van Rooijen, Richard A Strugnell, Odilia LC Wijburg

Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2007

Abstract

Interleukin-12 (IL-12) and IL-18 are both central to the induction of gamma interferon (IFN-gamma), and various roles for IL-12 and IL-18 in control of intracellular microbial infections have been demonstrated. We used IL-12p40(-/-) and IL-18(-/-) mice to further investigate the role of IL-12 and IL-18 in control of Salmonella enterica serovar Typhimurium. While C57BL/6 and IL-18(-/-) mice were able to resolve attenuated S. enterica serovar Typhimurium infections, the IL-12p40(-/-) mice succumbed to a high bacterial burden after 60 days. Using ovalbumin (OVA)-specific T-cell receptor transgenic T cells (OT-II cells), we demonstrated that following oral infection with recombinant S. enterica ..

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