Journal article

Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds

John Walker, Souravi Ghosh, Joanne Pagnon, Caterina Colantoni, Andrea Newbold, Weiguang Zeng, David C Jackson

VACCINE | ELSEVIER SCI LTD | Published : 2007


In this study we examine the immunogenicity of totally synthetic peptide-based immunocontraceptive vaccines in dogs. Seven individual epitope-based vaccines were assembled in which a different T helper (T(H)) cell epitope derived from the sequence of F protein of canine distemper virus was synthesized in tandem with a peptide representing luteinising hormone releasing hormone (LHRH). Each of the individual T(H)-LHRH peptide vaccines was inoculated subcutaneously into dogs. The results demonstrate that five of the seven peptide vaccines were able to elicit strong anti-LHRH antibody responses in beagle foxhounds accompanied by a concomitant suppression in the levels of the hormones testosteron..

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