Journal article

PTP sigma binds and dephosphorylates neurotrophin receptors and can suppress NGF-dependent neurite outgrowth from sensory neurons

Clare Faux, Muhamed Hawadle, Jennifer Nixon, Adam Wallace, Simon Lee, Simon Murray, Andrew Stoker

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | ELSEVIER SCIENCE BV | Published : 2007

Abstract

Neurotrophin receptors of the Trk family play a vital role in the survival of developing neurons and the process of axonogenesis. The Trk family are receptor protein tyrosine kinases (RTKs) and their signalling in response to neurotrophins is critically dependent upon their ability to transphosphorylate and act as signalling centres for multiple adaptor proteins and distinct, downstream pathways. Such phosphotyrosine signalling also depends upon the appropriate counter-regulation by phosphatases. A large family of receptor-like protein tyrosine phosphatases (RPTPs) are also expressed in developing neurons and in this study we have examined the ability of the phosphatase PTPsigma to interact ..

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University of Melbourne Researchers