Journal article

Mapping 5-HT inputs to enteric neurons of the guinea-pig small intestine

KB Neal, JC Bornstein

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2007

Abstract

5-HT released by gastrointestinal mucosa and enteric interneurons has powerful effects on gut behavior. However, the targets of 5-HT-containing neurons within enteric circuits are not well characterized. We used antisera against 5-HT and selected markers of known enteric neuron types to investigate the connections made by 5-HT-containing neurons in the guinea-pig jejunum. Confocal microscopy was used to quantify the number of 5-HT-immunoreactive varicosities apposed to immunohistochemically identified cell bodies. Large numbers of varicosities were identified apposing cholinergic secretomotor neurons, immunoreactive for neuropeptide Y, in both myenteric and submucous plexuses. Subgroups of n..

View full abstract

University of Melbourne Researchers