Journal article

Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: Results from the colon cancer family registry

Jenny N Poynter, Jane C Figueiredo, David V Conti, Kathleen Kennedy, Steven Gallinger, Kimberly D Siegnumd, Graham Casey, Stephen N Thibodeau, Mark A Jenkins, John L Hopper, Graham B Byrnes, John A Baron, Ellen L Goode, Maarit Tiirikainen, Noralane Lindor, John Grove, Polly Newcomb, Jeremy Jass, Joanne Young, John D Potter Show all

CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2007

Abstract

Recent publications have reported that common variants on 8q24 are associated with both prostate and colorectal cancers (CRC). In addition, one of these studies (the ARCTIC study) initially observed an association with a single nucleotide polymorphism (SNP) on 9p24 that was not confirmed in some of their validation data sets. In the research described here, we conducted a case-unaffected sibling analysis using population- and clinic-based discordant sibships (N = 1,567 sibships) from the Colon Cancer Family Registry (Colon CFR) to investigate the associations between common variants at 9p24 and 8q24 and risk of CRC. We also evaluated whether these associations differed by age, family history..

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