Journal article

Granulocyte colony-stimulating factor and an RARa specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells

Kirsten E Herbert, Carl R Walkley, Ingrid G Winkler, Jean Hendy, Gernma Haines Olsen, Yang-Dar Yuan, Roshantha AS Chandraratna, H Miles Prince, Jean-Pierre Levesque, Louise E Purton



BACKGROUND: Failure to mobilize adequate numbers of hematopoietic stem and progenitor cells (HSPC) is an important clinical problem. Since bone marrow (BM) neutrophils play a central role in HSPC mobilization, we hypothesized that granulocyte colony-stimulating factor (G-CSF)-mediated mobilization would be enhanced by further expanding the size of the BM granulocyte pool. METHODS: We tested the potential of the retinoic acid receptor alpha (RARalpha) specific agonist VTP195183, and the pan-RAR agonist all-trans retinoic acid (ATRA), to enhance G-CSF-mediated mobilization of HSPC, in two mouse strains. RESULTS: Pretreatment of mice with VTP195183 significantly increased the number of leukocyt..

View full abstract