Journal article

Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study

Mahesh Sathiavageeswaran, Pia Burman, David Lawrence, Alan G Harris, Marina G Falleti, Paul Maruff, John Wass

EUROPEAN JOURNAL OF ENDOCRINOLOGY | BIO SCIENTIFICA LTD | Published : 2007

Abstract

OBJECTIVE: Young adults with childhood-onset GH deficiency (GHD) have reduced memory and attention, which can be improved by treatment with GH. Little information is available on cognitive function in elderly GHD patients. DESIGN: Single center, double-blind, randomized, placebo-controlled study of 52-week duration. METHODS: Elderly GH therapy naïve GHD patients (n=34; age range 60-77 years) were enrolled and randomized to receive placebo or GH therapy which was titrated to achieve a target IGF-I level of +1 to +2 s.d. of the normal mean for age. Cognitive function was assessed at baseline and after 24 and 52 weeks, using a computerized psychometric test package (Neurobehavioral Examination ..

View full abstract

University of Melbourne Researchers