Journal article

Valsartan but not Atenolol improves vascular pathology in diabetic Ren-2 rat retina

Jennifer Louise Wilkinson-Berka, Genevieve Tan, Kassie Jaworski, Slavisa Ninkovic

AMERICAN JOURNAL OF HYPERTENSION | OXFORD UNIV PRESS | Published : 2007

Abstract

BACKGROUND: To determine whether angiotensin type 1 receptor blockade (AT1-RB) or antihypertensive therapy per se, attenuates acellular capillaries and proliferating endothelial cells in the retina of diabetic Ren-2 rats. METHODS: Eight-week-old hypertensive Ren-2 rats were made diabetic (streptozotocin, 55 mg/kg) or nondiabetic (0.1 mol/L citrate buffer) and studied for 20 weeks. Diabetic Ren-2 rats received by gavage the AT1-RB valsartan at 4, 10, or 40 mg/kg/d or the beta1-adrenergic receptor blocker atenolol at 30 mg/kg/d. Systolic blood pressure (BP) was measured every 4 weeks. Acellular capillaries (devoid of pericytes and endothelial cells) were counted on trypsin digests. Proliferati..

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