Journal article

Progressive fibrosis in nonalcoholic steato hepatitis: Association with altered regeneration and a ductular reaction

Michelle M Richardson, Julie R Jonsson, Elizabeth E Powell, Elizabeth M Brunt, Brent A Neuschwander-Tetri, Prithi S Bhathal, John B Dixon, Martin D Weltman, Herbert Tilg, Alexander R Moschen, David M Purdie, Anthony J Demetris, Andrew D Clouston

GASTROENTEROLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2007

Abstract

BACKGROUND & AIMS: Portal fibrosis and linkage is a key feature of progressive disease in nonalcoholic steatohepatitis (NASH), but not simple steatosis. It is underappreciated and poorly understood. Fatty liver has impaired regeneration that induces a secondary replicative pathway using bipotential, periportal, hepatic progenitor cells (HPCs). We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus. METHODS: Biopsy specimens from 107 patients with nonalcoholic fatty liver disease and 11 controls were immunostained with cytokeratin-7 to quantify the DR and HPCs, and with p21 to..

View full abstract

University of Melbourne Researchers