Journal article

Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance

Tan Pham, Anna Cornea, Kenneth E Blick, Alicia Jenkins, R Hal Scofield

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | ELSEVIER SCIENCE INC | Published : 2007

Abstract

BACKGROUND: Glucosamine is used to treat osteoarthritis. In animals, the compound is known to cause insulin resistance, the underlying abnormality in type 2 diabetes mellitus. Insulin resistance in humans taking oral glucosamine in doses used for osteoarthritis has not been studied. METHODS: Volunteer human subjects (n = 38) without known abnormality of glucose homeostasis had fasting serum glucose, insulin, and lipids determined before and after taking 1500 mg glucosamine by mouth every day for 6 weeks. Fasting insulin and glucose were used to calculate homeostasis model assessment (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Vascular elasticity was measured by pulse..

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