Journal article

Monocyte chemoattractant protein-1 and nitric oxide promote adipogenesis in a model that mimics obesity

Karsten Hemmrich, Gregory PL Thomas, Keren M Abberton, Erik W Thompson, John A Rophael, Anthony J Penington, Wayne A Morrison

OBESITY | WILEY | Published : 2007

Abstract

OBJECTIVE: An increasing body of evidence is emerging linking adipogenesis and inflammation. Obesity, alone or as a part of the metabolic syndrome, is characterized by a state of chronic low-level inflammation as revealed by raised plasma levels of inflammatory cytokines and acute-phase proteins. If inflammation can, in turn, increase adipose tissue growth, this may be the basis for a positive feedback loop in obesity. We have developed a tissue engineering model for growing adipose tissue in the mouse that allows quantification of increases in adipogenesis. In this study, we evaluated the adipogenic potential of the inflammogens monocyte chemoattractant protein (MCP)-1 and zymosan-A (Zy) in..

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