Journal article

Microscopic colitis demonstrates a T helper cell type 1 mucosal cytokine profile

Peter P Tagkalidis, Peter R Gibson, Prithi S Bhathal

JOURNAL OF CLINICAL PATHOLOGY | B M J PUBLISHING GROUP | Published : 2007

Abstract

BACKGROUND: Microscopic colitis (MC) is an inflammatory disorder of unknown aetiology. AIM: To characterise the mucosal cytokine profile of MC, with a view to understanding its potential pathogenic mechanisms. METHODS: Cytokine profiles of mucosal biopse specimens taken at flexible sigmoidoscopy from 18 patients (8 with lymphocytic colitis and 10 with collagenous colitis) were analysed using real-time reverse transcriptase-PCR, in comparison with those from 13 aged-matched controls with diarrhoea-predominant irritable bowel syndrome. Biopsy specimens from six patients with histologically documented remission were available for comparative analysis. Biopsy specimens were also taken to determi..

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University of Melbourne Researchers