Journal article

Quantitative characterization of regenerating axons after end-to-side and end-to-end coaptation in a rat brachial plexus model: A retrograde tracer study

Kanit Sananpanich, Mary P Galea, Wayne A Morrison, Aurora Messina

JOURNAL OF NEUROTRAUMA | MARY ANN LIEBERT INC | Published : 2007

Abstract

The efficacy of end-to-side repair as a method of nerve reconstruction has been questioned, and most studies that characterize the mode of re-innervation are marred by inappropriate experimental design and lack quantitative analysis. This makes characterization of re-innervating neurons confusing and consequently controversy remains as to the extent and source of reinnervating axons. In an experimental brachial plexus rat model, we transected the musculocutaneous nerve, labeled its neuron pool with Fast-Blue and joined the distal stump to the side of the intact ulnar nerve, or to the proximal stump of the divided ulnar nerve, to characterize neurons that reinnervate the recipient nerve. Tetr..

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