Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis B

GKK Lau; H Cooksley; RM Ribeiro; KA Powers; E Shudo; S Bowden; CK Hui; J Anderson; J Sorbel; E Mondou; F Rousseau; S Lewin; AS Perelson; S Locarnini; NV Naoumov

Journal article

Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis B

GKK Lau, H Cooksley, RM Ribeiro, KA Powers, E Shudo, S Bowden, CK Hui, J Anderson, J Sorbel, E Mondou, F Rousseau, S Lewin, AS Perelson, S Locarnini, NV Naoumov

Antiviral Therapy | Published : 2007

DOI: 10.1177/135965350701200513

Abstract

Background: The patterns of hepatitis B viral dynamics during different antiviral therapies and the associated changes in HBV-specific T-cell reactivity are not well defined. Methods: We investigated the impact of early viral load decline on virus-specific T-cell reactivity in 30 hepatitis B e antigen (HBeAg)-positive patients with chronic hepatitis B randomized to monotherapy with adefovir dipivoxil (ADV) or in combination with emtricitabine (ADV/FTC). Viral kinetics were analysed by mathematical modelling. T-cell reactivity to HBV core and/or surface antigens and natural killer T cell frequency were tested longitudinally, baseline to week 48, using EliSPOT assays and/or flow cytometry. Res..

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