Journal article

Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial

A Patel, S MacMahon, J Chalmers, B Neal, M Woodward, L Billot, S Harrap, N Poulter, M Marre, M Cooper, P Glasziou, DE Grobbee, P Hamet, S Heller, LS Liu, G Mancia, CE Mogensen, CY Pan, A Rodgers, B Williams

LANCET | ELSEVIER SCIENCE INC | Published : 2007

Abstract

BACKGROUND: Blood pressure is an important determinant of the risks of macrovascular and microvascular complications of type 2 diabetes, and guidelines recommend intensive lowering of blood pressure for diabetic patients with hypertension. We assessed the effects of the routine administration of an angiotensin converting enzyme (ACE) inhibitor-diuretic combination on serious vascular events in patients with diabetes, irrespective of initial blood pressure levels or the use of other blood pressure lowering drugs. METHODS: The trial was done by 215 collaborating centres in 20 countries. After a 6-week active run-in period, 11 140 patients with type 2 diabetes were randomised to treatment with ..

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