Heterogeneity and oxidation status of commercial human albumin preparations in clinical use

Abstract

Objective: Human serum albumin is indicated for the treatment of shock, acute restoration of blood volume, and in hypoalbuminemia. Conflicting reports are found in the literature for the clinical safety and efficacy of human serum albumin administration to critically ill patients. We sought to analyze various commercially available albumin preparations for common, posttranslational modifications. Design: Analysis of six commercially available albumin preparations for clinical use. Setting: Trauma research laboratory. Subjects: Commercially available human serum albumin preparations and healthy volunteers. Interventions: Six commercially available human serum albumin preparations were analyze..