Journal article

Heritability of anterior chamber depth as an intermediate phenotype of angle-closure in Chinese: The Guangzhou twin eye study

Mingguang He, Dandan Wang, Yingfeng Zheng, Jian Zhang, Qiuxia Yin, Wenyong Huang, David A Mackey, Paul J Foster

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2008

Abstract

PURPOSE: To assess the heritability of anterior chamber depth (ACD) and relative anterior chamber depth (ACD/axial length, rACD) in Chinese in a classic twin study. METHODS: Twins aged 7 to 15 years living in two local districts were recruited from the Guangzhou Twin Registry. Anterior chamber depth and axial length were measured by partial coherence laser interferometry. Zygosity in all same-sex twin pairs was confirmed by genotyping with 16 polymorphic markers. The phenotypes of the right eyes were used in analysis. Heritability was assessed by structural variance component genetic modeling. RESULTS: In total, 1126 twin participants were available for analysis, including 357 monozygotic (M..

View full abstract