Journal article

The natural history and prognosis of neovascular age-related macular degeneration

Tien Wong, Usha Chakravarthy, Ronald Klein, Paul Mitchell, Gergana Zlateva, Ronald Buggage, Kyle Fahrbach, Corey Probst, Isabella Sledge

OPHTHALMOLOGY | ELSEVIER SCIENCE INC | Published : 2008

Abstract

PURPOSE: To describe the natural history and progression of visual loss in eyes with untreated neovascular age-related macular degeneration (AMD). DESIGN: Systematic review and meta-analysis. PARTICIPANTS: Four thousand three hundred sixty-two untreated neovascular AMD patients from published interventional studies. METHODS: A systematic review of the literature from 1980 to August 2005 was performed. Studies reporting disease progression outcomes for untreated patients with neovascular AMD were included. Outcome measures were summarized using simple counts and means. Random effects meta-analyses were conducted and tests of heterogeneity were performed where appropriate. MAIN OUTCOME MEASURE..

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