Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects

S Patel; A Flyvbjerg; M Kozàkovà; J Frystyk; IM Ibrahim; JR Petrie; PJ Avery; E Ferrannini; M Walker; RJ Heine; J Dekker; G Nijpels; W Boorsma; A Mitrakou; S Tournis; K Kyriakopoulou; P Thomakos; N Lalic; K Lalic; A Jotic; L Lukic; M Civcic; J Nolan; TP Yeow; M Murphy; C DeLong; G Neary; MP Colgan; M Hatunic; T Konrad; H Böhles; S Fuellert; F Baer; H Zuchhold; A Golay; E Harsch Bobbioni; V Barthassat; V Makoundou; TNO Lehmann; T Merminod; C Perry; F Neary; C MacDougall; K Shields; L Malcolm; M Laakso; U Salmenniemi; A Aura; R Raisanen; U Ruotsalainen; T Sistonen; M Laitinen; H Saloranta; SW Coppack; N McIntosh; P Khadobaksh; M Laville; F Bonnet; A Brac De La Perriere; C Louche-Pelissier; C Maitrepierre; J Peyrat; A Serusclat; R Gabriel; EM Sánchez; R Carraro; A Friera; B Novella; P Nilsson; M Persson; G Östling; O Melander; P Burri; PM Piatti; LD Monti; E Setola; E Galluccio; F Minicucci; A Colleluori; M Walker; IM Ibrahim; M Jayapaul; D Carman; K Short; Y McGrady; D Richardson; H Beck-Nielsen; P Staehr; K Hojlund; V Vestergaard; C Olsen; L Hansen; GB Bolli; F Porcellati; C Fanelli; P Lucidi; F Calcinaro; A Saturni; E Ferrannini; A Natali

Journal article

Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects

S Patel, A Flyvbjerg, M Kozàkovà, J Frystyk, IM Ibrahim, JR Petrie, PJ Avery, E Ferrannini, M Walker, RJ Heine, J Dekker, G Nijpels, W Boorsma, A Mitrakou, S Tournis, K Kyriakopoulou, P Thomakos, N Lalic, K Lalic, A Jotic Show all

European Heart Journal | OXFORD UNIV PRESS | Published : 2008

DOI: 10.1093/eurheartj/ehm526

Abstract

Aims: The ADIPOQ gene encodes the protein adiponectin, and decreased circulating adiponectin levels have been observed in cardiovascular disease. We investigated the role of the ADIPOQ gene single-nucleotide polymorphisms (SNPs) A-11426G, G-11391A, C-11377G, and T45G with plasma adiponectin levels and common carotid artery intima media thickness (IMT) in a cohort of healthy subjects participating in the RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) study. Methods and results: Anthropometric and metabolic assessment and B-mode ultrasound of the carotid IMT were measured in 1306 subjects [589 men; 717 women, mean ± SD age 43.8 ± 8.3 years, BMI 25.5 ± 4.0 kg/m2] rec..

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