Journal article

Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects

Sheila Patel, Allan Flyvbjerg, Michaela Kozakova, Jan Frystyk, Ibrahim M Ibrahim, John R Petrie, Peter J Avery, Ele Ferrannini, Mark Walker

EUROPEAN HEART JOURNAL | OXFORD UNIV PRESS | Published : 2008

Abstract

AIMS: The ADIPOQ gene encodes the protein adiponectin, and decreased circulating adiponectin levels have been observed in cardiovascular disease. We investigated the role of the ADIPOQ gene single-nucleotide polymorphisms (SNPs) A-11426G, G-11391A, C-11377G, and T45G with plasma adiponectin levels and common carotid artery intima media thickness (IMT) in a cohort of healthy subjects participating in the RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) study. METHODS AND RESULTS: Anthropometric and metabolic assessment and B-mode ultrasound of the carotid IMT were measured in 1306 subjects [589 men; 717 women, mean +/- SD age 43.8 +/- 8.3 years, BMI 25.5 +/- 4.0 kg/m..

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University of Melbourne Researchers