Journal article

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

Laura Pascoe, Andrea Tura, Sheila K Patel, M Ibrahim Ibrahim, Ele Ferrannini, Eleftheria Zeggini, Michael N Weedon, Andrea Mari, Andrew T Hattersley, Mark I McCarthy, Timothy M Frayling, Mark Walker



OBJECTIVE: Type 2 diabetes is characterized by impaired pancreatic beta-cell function and decreased insulin sensitivity. Genome-wide association studies have identified common, novel type 2 diabetes susceptibility loci within the FTO, CDKAL1, CDKN2A/CDKN2B, IGF2BP2, HHEX/IDE, and SLC30A8 gene regions. Our objective was to explore the relationships between the diabetes-associated alleles and measures of beta-cell function and whole-body insulin sensitivity. RESEARCH DESIGN AND METHODS: A total of 1,276 healthy subjects of European ancestry were studied at 19 centers. Indexes of beta-cell function (including 30-min insulin response and glucose sensitivity) were derived from a 75-g oral glucose..

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University of Melbourne Researchers