Journal article
Heritability of the iridotrabecular angle width measured by optical coherence tomography in chinese children: The guangzhou twin eye study
M He, J Ge, D Wang, J Zhang, AW Hewitt, YM Hur, DA Mackey, PJ Foster
Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2008
DOI: 10.1167/iovs.07-1397
Abstract
Purpose. To estimate the heritability of the iridotrabecular angle width measured by anterior segment optical coherence tomography (ASOCT) in a classic twin study. Methods. Twins aged 8 to 16 years were identified from the Guangzhou Twin Registry. ASOCT was used to obtain one horizontal scan and the images were analyzed with custom software. Angle width was represented by the angle opening distance (AOD) at the 500-μm anterior-to-scleral spur as well as the angle recess area (ARA) and trabecular-iris space area (TISA) located 750 μm anterior to the scleral spur. Zygosity was confirmed by genotyping with 16 polymorphic markers in all same-sex twin pairs. Heritability was assessed by structura..
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