Journal article

Synthesis and cannabinoid activity of 1-sub stituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor

Gerard P Moloney, James A Angus, Alan D Robertson, Martin J Stoermer, Michael Robinson, Christine E Wright, Ken McRae, Arthur Christopoulos

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2008

Abstract

An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB(1) agonists. It is hoped that compounds of this type will have clinical utility in pain control, and cerebral ischaemia following stroke or traumatic head injury. We report here medicinal chemistry studies directed towards the investigation of a series of 1-substituted-indole-3-oxadiazoles as potential CB(1) agonists.