Journal article

Macrophages are mediators of gastritis in acute Helicobacter pylori infection in C57BL/6 mice

Maria Kaparakis, Anna K Walduck, Jason D Price, John S Pedersen, Nico Van Rooijen, Martin J Pearse, Odilia LC Wijburg, Richard A Strugnell

INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 2008

Abstract

Helicobacter pylori is the etiological agent of human chronic gastritis, a condition seen as a precursor to the development of gastrointestinal ulcers or gastric cancer. This study utilized the murine model of chronic H. pylori infection to characterize the role of macrophages in the induction of specific immune responses and gastritis and in the control of the bacterial burden following H. pylori infection and vaccination. Drug-loaded liposomes were injected intravenously to deplete macrophages from C57BL/6 mice, and effective removal of CD11b+ cells from the spleens and stomachs of mice was confirmed by immunofluorescence microscopy. Transient elimination of macrophages from C57BL/6 mice d..

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