Journal article

Embryonic stem cells markers are present within rabbit atherosclerotic plaques

Anthony Zulli, Brian F Buxton, M Jane Black, David L Hare

Histology and Histopathology: cellular and molecular biology | F HERNANDEZ | Published : 2008

Abstract

UNLABELLED: Recent evidence suggests that smooth muscle cells within atherosclerotic plaques originate from vascular progenitor cells. We have previously shown that smooth muscle cells and macrophages present within rabbit atherosclerotic plaques are positive for factors of the renin angiotensin and nitric oxide systems as well as the hematopoietic stem-cell marker CD34 and the pan-leukocyte marker CD45. To explore the idea that these cells are of primitive types, immunohistochemistry was used to identify pluripotent embryonic stem cells (ESC) markers (Oct-4, SSEA1,3,4, TRA1-60, 81) in these plaques and to compare these to intimal thickening. OBJECTIVE: To immunolocalise ESC markers in rabbi..

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University of Melbourne Researchers