Journal article

Alterations in vascular architecture and permeability following OXi4503 treatment

Lie Sam Chan, Cathy Malcontenti-Wilson, Vijayaragavan Muralidharan, Christopher Christophi

ANTI-CANCER DRUGS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2008

Abstract

OXi4503 retards tumor growth in a dose-dependent manner and improves survival in a murine model of colorectal liver metastases. This agent causes extensive vascular shutdown by selectively altering the tubulin cytoskeleton within the endothelial cells of tumor vessels. The destruction of tumor vessels is incomplete, however, and tumor revascularization occurs after the treatment. This study evaluates the pattern of microcirculatory changes and alterations to the ultrastructural properties of the tumor vasculature that result from OXi4503 treatment. Male CBA mice were induced with liver metastases via an intrasplenic injection of a murine-derived colorectal cell line. After administering a si..

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