Journal article

Hyperbaric oxygen improves capillary morphology in severe acute pancreatitis

Christine M Cuthbertson, Kim H Su, Vijayagavan Muralidharan, Ian Millar, Caterina Malcontenti-Wilson, Christopher Christophi

PANCREAS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2008

Abstract

OBJECTIVES: This article aims to determine the effect of acute pancreatitis on microvascular morphology and the impact of treatment with hyperbaric oxygen (HBO). METHODS: Sixty-seven male Wistar rats were induced with acute pancreatitis by retrograde bile duct injection. Rats were randomized to 12-hourly HBO or control treatment. Two rats in each group were killed at baseline and 24, 48, and 72 hours postinduction, and a cast of the pancreatic microvasculature was examined using scanning electron microscopy. RESULTS: Normal pancreatic vasculature is a dense network with a consistent capillary diameter. In acute pancreatitis, mean capillary diameter is increased at 24 hours (P < 0.001) and fu..

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