Journal article

Human leukocyte antigen mismatch and other factors affecting cryopreserved allograft valve function

Cheng-Hon Yap, Peter D Skillington, George Matalanis, Bruce B Davis, Brian D Tait, Fiona Hudson, Lyn Ireland, Ian Nixon, Michael Yii

HEART SURGERY FORUM | FORUM MULTIMEDIA PUBLISHING, LLC | Published : 2008

Abstract

The causes of cryopreserved allograft heart valve degeneration are poorly understood. We investigated HLA mismatch and other factors implicated in allograft valve degeneration. For this study we recruited 110 adult recipients of allograft heart valves who underwent surgery between June 1998 and March 2003 in the state of Victoria, Australia. Recipients and donors were HLA typed using serological and molecular methods. Valve function at most recent echocardiographic follow-up was examined for an association with the following variables using univariate and multivariate methods: HLA-A,-B, and -DR donor-recipient mismatch; HLA class I mismatch; total HLA mismatch; valve ischemic time; recipient..

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