Journal article

B-type natriuretic peptides strongly predict mortality in patients who are treated with long-term dialysis

Matthew A Roberts, Piyush M Srivastava, Neil Macmillan, David L Hare, SuJiva Ratnaike, Ken Sikaris, Francesco L Ierino

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | AMER SOC NEPHROLOGY | Published : 2008

Abstract

BACKGROUND AND OBJECTIVES: Left ventricular abnormalities contribute to cardiovascular disease in patients with chronic kidney disease and may be detected by measurement of B-type natriuretic peptide in serum. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a prospective cohort study of predialysis patients, patients who were on dialysis, and kidney transplant recipients, serum was collected and assayed for both B-type natriuretic peptide and its N-terminal fragment. Median levels were compared using nonparametric tests, and predictors of B-type natriuretic peptide were determined by linear regression. Survival analysis and Cox regression were performed to examine the association of levels..

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