Journal article

Gender differences in outcome in patients with hypotension and severe traumatic brain injury

Jennie L Ponsford, Paul S Myles, D James Cooper, Francis T Mcdermott, Lynnette J Murray, John Laidlaw, Gregory Cooper, Ann B Tremayne, Stephen A Bernard

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | ELSEVIER SCI LTD | Published : 2008

Abstract

BACKGROUND: Animal studies have identified hormonal influences on responses to injury and recovery, creating a potential gender effect on outcome. Progesterone and oestrogen are thought to afford protection in the immediate post-injury period, suggesting females have an advantage, although there has been limited evidence of this in human outcome studies. METHODS: This study examined the influence of gender on outcome in 229 adults (151 males), aged >17 years, with severe blunt head trauma, initial GCS 4) at 6 months, but this appeared to reflect the lower rate of initial survival. Those females surviving had similar outcomes to males. CONCLUSIONS: The study provides no evidence that females ..

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