Journal article

The emergence of depression in adolescence: Development of the prefrontal cortex and the representation of reward

Christopher G Davey, Murat Yucel, Nicholas B Allen

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2008

Abstract

Adolescent development is accompanied by the emergence of a population-wide increase in vulnerability to depression that is maintained through adulthood. We provide a model for understanding how this vulnerability to depression arises, and why depression is so often precipitated by social rejection or loss of status during this phase. There is substantial remodeling and maturation of the dopaminergic reward system and the prefrontal cortex during adolescence, that coincides with the adolescent entering the complex world of adult peer and romantic relationships, where the rewards that can be obtained (feelings such as belonging, romantic love, status and agency) are abstract and temporally di..

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