Journal article

Maternal-fetal DNA admixture is associated with intrapartum mother-to-child transmission of HIV-1 in Blantyre, Malawi

Jesse J Kwiek, Leslie A Arney, Visopo Harawa, Bonnie Pedersen, Victor Mwapasa, Stephen J Rogerson, Steven R Meshnick

JOURNAL OF INFECTIOUS DISEASES | UNIV CHICAGO PRESS | Published : 2008

Abstract

BACKGROUND: The mechanism of mother-to-child transmission (MTCT) of HIV-1 is not well described. METHODS: Of 328 HIV-infected mother-infant pairs, we identified 91 that had discordant angiotensin I-converting enzyme and glutathione S-transferase M1 alleles. Maternal alleles in cord blood were quantified with real-time polymerase chain reaction, as indicators of microtransfusions. RESULTS: HIV-1 infected infants had more maternal DNA in cord blood than their uninfected counterparts. Increased maternal DNA in cord blood was associated with preterm delivery, low birth weight, and maternal immunosuppression. CONCLUSION: Intrapartum MTCT was associated with placental microtransfusions. The associ..

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University of Melbourne Researchers