Journal article

Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats

Harrison S Weisinger, Denovan P Begg, Gary F Egan, Anura P Jayasooriya, Fanny Lie, Michael L Mathai, Andrew J Sinclair, John D Wark, Richard S Weisinger

PHYSIOLOGY & BEHAVIOR | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2008

Abstract

In vitro studies have demonstrated that angiotensin II (ANG II) induces adipocyte hyperplasia and hypertrophy. The aim of the present study was to determine the effect of angiotensin-converting enzyme inhibition on body weight, adiposity and blood pressure in Sprague-Dawley rats. From birth half of the animals (n=15) were given water to drink, while the remainder were administered perindopril in their drinking water (2 mg/kg/day). Food intake, water intake and body weight were measured weekly. Blood pressure was measured by tail cuff plethysmography at 11-weeks. Body fat content and distribution were assessed using dual energy X-ray absorptiometry and Magnetic Resonance Imaging at 12 weeks. ..

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