Genetic Dissection of Myopia. Evidence for Linkage of Ocular Axial Length to Chromosome 5q

Abstract

Purpose: To estimate heritability and locate quantitative trait loci influencing axial length. Design: Classic twin study of monozygotic and dizygotic twins reared together. Participants: Eight hundred ninety-three individuals from 460 families were recruited through the Twin Eye Study in Tasmania and the Brisbane Adolescent Twin Study (BATS) and had ocular axial length measured. Methods: Structural equation modeling on the entire sample was used to estimate genetic and environmental components of variation in axial length. Analysis of existing microsatellite marker genomewide linkage scan data was performed on 318 individuals from 142 BATS families. Main Outcome Measure: Ocular axial length..