Journal article

Rotavirus infection accelerates type 1 diabetes in mice with established insulitis

Kate L Graham, Natalie Sanders, Yan Tan, Janette Allison, Thomas WH Kay, Barbara S Coulson

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2008

Abstract

Infection modulates type 1 diabetes, a common autoimmune disease characterized by the destruction of insulin-producing islet beta cells in the pancreas. Childhood rotavirus infections have been associated with exacerbations in islet autoimmunity. Nonobese diabetic (NOD) mice develop lymphocytic islet infiltration (insulitis) and then clinical diabetes, whereas NOD8.3 TCR mice, transgenic for a T-cell receptor (TCR) specific for an important islet autoantigen, show more rapid diabetes onset. Oral infection of infant NOD mice with the monkey rotavirus strain RRV delays diabetes development. Here, the effect of RRV infection on diabetes development once insulitis is established was determined. ..

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