Interleukin-1 receptor antagonist in human cervicovaginal fluid in term pregnancy and labor
Yujing J Heng, Megan KW Di Quinzio, Michael Permezel, Gregory E Rice, Harry M Georgiou
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | MOSBY-ELSEVIER | Published : 2008
OBJECTIVE: The objective of the study was to investigate temporal changes in interleukin-1 receptor antagonist (IL-1ra) in human cervicovaginal fluid (CVF) in term pregnancy and labor. STUDY DESIGN: CVF was collected weekly from 155 multiparous women from 36 weeks' gestation until labor. High vaginal swabs were collected for microbiology assessment. RESULTS: IL-1ra was decreased in spontaneous term labor, compared with 15-21 and 22-28 days from labor, and was significantly lower at 0-7 days, compared with 15-21 days before labor (P < .05, 2-way ANOVA). After subdividing the women, IL-1ra concentrations were 6-fold lower in women who had prelabor rupture of membranes at term than women who ha..View full abstract
Awarded by National Health and Medical Research Council of Australia ( NHMRC)
This study was supported by a National Health and Medical Research Council of Australia ( NHMRC) development grant ( 454451) and the Medical Research Foundation for Women and Babies. Y. J. H. is a recipient of the NHMRC Biomedical ( Dora Lush) postgraduate research scholarship ( 454880).