Evaluation of Intrastromal Injection of Voriconazole as a Therapeutic Adjunctive for the Management of Deep Recalcitrant Fungal Keratitis

Abstract

Purpose: To evaluate the role of intrastromal injection of voriconazole in the management of deep recalcitrant fungal keratitis. Design: Interventional case series. Methods: Setting: Cornea services at a tertiary care teaching hospital. Patients: Three eyes of three patients with deep stromal recalcitrant fungal keratitis not responding to topical antifungal medications. Intervention Procedure: Voriconazole 50 micrograms/0.1 ml was injected circumferentially around the fungal abscess in the corneal stroma as an adjunctive to the topical antifungal therapy. Main Outcome Measure: Main outcome measure was a reduction in size of the abscess and resolution of the infection. Results: Before the in..