Journal article

Evaluation of intrastromal injection of voriconazole as a therapeutic adjunctive for the management of deep recalcitrant fungal keratitis

Gaurav Prakash, Namrata Sharma, Manik Goel, Jeewan S Titiyal, Rasik B Vajpayee

AMERICAN JOURNAL OF OPHTHALMOLOGY | ELSEVIER SCIENCE INC | Published : 2008

Abstract

PURPOSE: To evaluate the role of intrastromal injection of voriconazole in the management of deep recalcitrant fungal keratitis. DESIGN: Interventional case series. METHODS: SETTING: Cornea services at a tertiary care teaching hospital. PATIENTS: Three eyes of three patients with deep stromal recalcitrant fungal keratitis not responding to topical antifungal medications. Intervention Procedure: Voriconazole 50 micrograms/0.1 ml was injected circumferentially around the fungal abscess in the corneal stroma as an adjunctive to the topical antifungal therapy. MAIN OUTCOME MEASURE: Main outcome measure was a reduction in size of the abscess and resolution of the infection. RESULTS: Before the i..

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