Journal article

CD4( ) target cell availability determines the dynamics of immune escape and reversion in vivo

Janka Petravic, Liyen Loh, Stephen J Kent, Miles P Davenport

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2008

Abstract

Infections with human immunodeficiency virus (HIV) and the closely related monkey viruses simian-human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) are characterized by progressive waves of immune responses, followed by viral mutation and "immune escape." However, escape mutation usually leads to lower replicative fitness, and in the absence of immune pressure, an escape mutant (EM) virus "reverts" to the wild-type phenotype. Analysis of the dynamics of immune escape and reversion has suggested it is a mechanism for identifying the immunogens best capable of controlling viremia. We have analyzed and modeled data of the dynamics of wild-type (WT) and EM viruses during..

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University of Melbourne Researchers