Journal article
Progressive changes in the development toward schizophrenia: Studies in subjects at increased symptomatic risk
Stephen J Wood, Christos Pantelis, Dennis Velakoulis, Murat Yuecel, Alex Fornito, Patrick D McGorry
SCHIZOPHRENIA BULLETIN | OXFORD UNIV PRESS | Published : 2008
Abstract
Although the underlying neurobiology of emerging psychotic disorders is not well understood, there is a growing conviction that the study of patients at clinical high risk for the illness will provide important insights. Further, a better understanding of the transition period may help the development of novel therapies. In this review, we summarize the extant neuroimaging and neuropsychological studies of people at clinical high risk for psychosis. By and large, there are few definitive markers that distinguish those who go on to develop the illness from those who do not. The 2 most consistently abnormal brain regions in schizophrenia research, the hippocampi and the lateral ventricles, are..
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