Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespan
Ian M Colrain, Kate E Crowley, Christian L Nicholas, Lamia Afifi, Fiona C Baker, Mayra Padilla, Sharon R Turlington, John Trinder
NEUROBIOLOGY OF AGING | ELSEVIER SCIENCE INC | Published : 2010
Aging is associated with many changes in sleep, with one of the most prominent being a reduction in slow wave sleep. Traditional measures of this phenomenon rely on spontaneous activity and typically confound the incidence and amplitude of delta waves. The measurement of evoked K-complexes during sleep, enable separate assessment of incidence and amplitude taken from the averaged K-complex waveform. The present study describes data from 70 normal healthy men and women aged between 19 and 78 years. K-Complexes were evoked using short auditory tones and recorded from a midline array of scalp sites. Significant reductions with age were seen in the amplitude of the N550 component of the averaged..View full abstract
Awarded by NIH (NIAAA)
The work was funded by NIH (NIAAA) grant AA14211.