Journal article

Virus-specific T-cell immunity correlates with control of GB virus B infection in marmosets

David J Woollard, Gholarnreza Haqshenas, Xuebin Dong, Bridget F Pratt, Stephen J Kent, Eric J Gowans

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2008

Abstract

GB virus B (GBV-B) is a hepatotropic virus that is closely related to hepatitis C virus (HCV). GBV-B causes acute hepatitis in infected marmosets and tamarins and is therefore a useful small-animal model for the study of HCV. We investigated virus-specific T-cell responses in marmosets infected with GBV-B. Gamma interferon (IFN-gamma) enzyme-linked immunospot (ELISPOT) assay responses in the peripheral blood of two marmosets were assessed throughout the course of GBV-B infection. These T-cell responses were directed against the GBV-B nonstructural proteins 3 (NS3), 4A (NS4A), and 5B (NS5B), and their appearance was temporally associated with clearance of viremia. These marmosets were then re..

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